Bacteria-triggered release of a potent biocide from core-shell polyhydroxyalkanoate (PHA)-based nanofibers for wound dressing application

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Date
2018-09-25
Authors
Li, Wei
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Abstract
Bacterial infection is a serious issue in wound healing. Extensive use of biocides in wound dressings have raised concerns like biocide resistance and unwanted harm to normal skin cells. In this thesis, I report a new approach to realize bacteria-triggered release of biocide to the sites of bacterial infections from core-shell polyhydroxyalkanoate (PHA)-based nanofibers prepared by coaxial electrospinning. The hydrophobic PHA-based shell can effectively prevent the biocide from undesirable payload release in physiological environments without pathogens. However, in the presence of pathogens, the PHA-based shell is degraded by pathogens, and the encapsulated biocide is released. The released biocide subsequently can impose targeted antimicrobial effects on the bacteria. Using Pseudomonas aeruginosa as a model bacterium and dodecyltrimethylammonium chloride as a model biocide, we demonstrated that the core-shell PHA-based nanofibers released encapsulated dodecyltrimethylammonium chloride in the presence of Pseudomonas aeruginosa, resulting in targeted inhibition of Pseudomonas aeruginosa growth.
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Keywords
Polyhydroxyalkanoates, Nanofibers, Electrospinning, Wound dressing application
Citation
Li, W., Cicek, N., Levin, D. B., & Liu, S. (2018). Enabling electrospinning of medium-chain length polyhydroxyalkanoates (PHAs) by blending with short-chain length PHAs. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-11. doi: 10.1080/00914037.2018.1466136