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dc.contributor.author Targownik, Laura
dc.contributor.author Leslie, William
dc.contributor.author Carr, Rachel
dc.contributor.author Clara, Ian
dc.contributor.author Miller, Norine
dc.contributor.author Rogala, Linda
dc.contributor.author Graff, Lesley A.
dc.contributor.author Walker, John
dc.contributor.author Bernstein, Charles N.
dc.date.accessioned 2015-05-11T17:50:05Z
dc.date.available 2015-05-11T17:50:05Z
dc.date.issued 2012-11
dc.identifier.citation Calcif Tissue Int. 2012 Nov;91(5):356-63 en_US
dc.identifier.uri http://hdl.handle.net/1993/30424
dc.description.abstract Persons with inflammatory bowel disease (IBD) are reported to have a high prevalence of osteoporosis and reduced bone mineral density (BMD) and to be at higher risk of fracture. The course of BMD loss over time is poorly characterized in persons with IBD. Eighty-six persons, stratified by age, were enrolled from a population-based longitudinal IBD cohort study to undergo BMD testing at baseline, with final BMD testing a mean of 4.3 years later. The proportion of subjects with significant change in BMD at the lumbar spine, total hip, and femoral neck was assessed, as were clinical, biochemical, and anthropomorphic changes. Vertebral radiographs were also obtained at baseline and at the end of follow-up in those aged 50 years and above to detect vertebral fractures. The change in BMD seen in this cohort of IBD patients was similar to the expected rate of BMD loss in the general population. Age >50 years, decreasing body mass index (BMI), and corticosteroid use were most notably correlated with BMD loss. Subjects aged <50 years did not have statistically significant declines in BMD. IBD symptom activity scores correlated poorly with BMD loss. Vertebral fractures were uncommon, with only two subjects out of 41 >50 years old developing a definite radiographic fracture over the course of follow-up. No major nonvertebral fractures were observed. Patients with IBD do not appear to have significantly accelerated BMD loss. Older age, decreasing BMI, and corticosteroid use may identify IBD patients at greater risk for BMD loss. en_US
dc.language.iso en en_US
dc.publisher Calcified Tissue International en_US
dc.relation.ispartofseries 91(5);356-63
dc.rights info:eu-repo/semantics/openAccess
dc.subject BMD en_US
dc.subject Inflammatory Bowel Disease en_US
dc.subject Cohort en_US
dc.subject Population en_US
dc.subject Bernstein en_US
dc.title Longitudinal Change in BMD in a Population Based Cohort of Patients with Inflammatory Bowel Disease en_US
dc.type Article en_US
dc.type Dataset en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi 10.1007/s00223-012-9650-1


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