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dc.contributor.author Clara, Ian
dc.contributor.author Lix, LIsa
dc.contributor.author Walker, John R.
dc.contributor.author Graff, Lesley A.
dc.contributor.author Miller, Norine
dc.contributor.author Rogala, Linda
dc.contributor.author Rawsthorne, Patricia
dc.contributor.author Bernstein, Charles N.
dc.date.accessioned 2015-05-11T17:47:30Z
dc.date.available 2015-05-11T17:47:30Z
dc.date.issued 2009-07
dc.identifier.citation Am J Gastroenterol. 2009 Jul;104(7):1754-63 en_US
dc.identifier.uri http://hdl.handle.net/1993/30422
dc.description.abstract OBJECTIVES: A single-item indicator of disease activity over an extended period of time, the Manitoba Inflammatory Bowel Disease Index (MIBDI), is introduced and compared against several standard measures for assessing activity in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Participants enrolled in the Manitoba IBD Cohort Study, a population-based longitudinal cohort study (N=353), were assessed semiannually by survey, clinical interview, and blood sample during a 2-year period. The MIBDI is based on patient self-reports of symptom persistence for the previous 6 months, using a 6-level response format. RESULTS: The MIBDI had good sensitivity compared with the Harvey-Bradshaw Index (HB; 0.88), Powell-Tuck Index (PT; 0.84), and Inflammatory Bowel Disease Questionnaire (IBDQ; 0.89), which was maintained at two subsequent annual measurements. Test-retest reliability was also strong (Spearman's r=0.81). Discriminant function analyses identified common discriminating variables of active disease for CD and UC that included HB, PT, and IBDQ subscales of bowel and systemic symptoms, prolonged symptom severity (e.g., abdominal and joint pain, tiredness, diarrhea), and recent persistent pain related to IBD. Unique discriminators included weight problems (CD) and blood in stool (UC). CONCLUSIONS: A single-item, patient-defined disease activity measure, the MIBDI, showed a high degree of sensitivity for classifying individuals with regard to disease status over time compared with the existing disease activity measures, and strong convergent validity with expected proxy measures of disease. These relationships remained consistent over time. Thus, the MIBDI shows promise as a valid, brief tool for measuring disease activity over an extended period. en_US
dc.language.iso en en_US
dc.publisher American Journal Gastroenterology en_US
dc.relation.ispartofseries 104(7);1754-63
dc.rights info:eu-repo/semantics/openAccess
dc.subject IBD en_US
dc.subject Disease en_US
dc.subject Activity en_US
dc.subject Charles en_US
dc.subject Bernstein en_US
dc.title The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity en_US
dc.type Article en_US
dc.type Dataset en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi 10.1038/ajg.2009.197


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