CJIDMM Canadian Journal of Infectious Diseases 1180-2332 Pulsus Group Inc 210742 10.1155/1998/210742 Original Article Ciprofloxacin or Imipenem Use Correlates with Resistance in Pseudomonas aeruginosa Zhanel George G ggzhanel@pcs.mb.ca 1 2 Nicolle Lindsay E 1 2 Gin Alfred S 2 Karlowsky James 1 Kabani Amin 1 2 Hoban Daryl J 1 2 1 Departments of Medicine and Medical Microbiology and Faculties of Medicine and Pharmacy University of Manitoba Winnipeg Manitoba Canada umanitoba.ca 2 Departments of Medicine Clinical Microbiology and Pharmaceutical Services Health Sciences Centre Winnipeg Manitoba Canada hsc.mb.ca 1998 9 6 382 386 20 11 1997 26 3 1998 1998 Copyright © 1998 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http://creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.

OBJECTIVE: To investigate the relationship between ciprofloxacin or imipenem use and antimicrobial resistance in Pseudomonas aeruginosa.

METHODS: A retrospective review of monthly antimicrobial susceptibility reports for ciprofloxacin (1988 to 1995) and imipenem (1987 to 1995) against P aeruginosa and hospital antimicrobial use records at a tertiary care teaching hospital in Winnipeg, Manitoba. Data were entered into a relational database, R:Base 4.5++, collated, transferred to a spreadsheet and subjected to linear regression analysis. The relationship between ciprofloxacin or imipenem use and resistance was assessed using a Pearson correlation.

RESULTS: Ciprofloxacin-resistant P aeruginosa increased from 1.0% of all isolates in 1988 to 10.0% in 1995. A significant (P=0.05) correlation was demonstrated between the amount of ciprofloxacin use and prevalence of ciprofloxacin-resistant P aeruginosa (r=0.73, P=0.05). Imipenem-resistant P aeruginosa increased from 1.0% of isolates in 1987 to a maximum of 10.4% in 1991, and subsequently decreased to 5.4% in 1995. Imipenem use and the prevalence of imipenem-resistant P aeruginosa were significantly correlated (r=0.85, P=0.014).

CONCLUSIONS: Ciprofloxacin use was directly associated with ciprofloxacin resistance, and imipenem use was directly associated with imipenem resistance in P aeruginosa.

 Ciprofloxacin Imipenem Resistance Pseudomonas aeruginosa http://dx.doi.org/10.13039/100008793 Manitoba Health Research Council Allied Health Research Foundation