CJIDMM Canadian Journal of Infectious Diseases 1180-2332 Pulsus Group Inc 260839 10.1155/1992/260839 Original Article Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method Chagla Abdul H Hii John H Hoban Daryl J Simor Andrew E Ferro Santiago Witwicki Evelyn Poon Ruby Low Donald E 1 Departments of Microbiology Mount Sinai Hospital University of Toronto Toronto, Ontario Canada utoronto.ca 2 Health Sciences Centre University of Manitoba Winnipeg, Manitoba Canada umanitoba.ca 1992 3 5 231 234 17 5 1991 26 8 1991 1992 Copyright © 1992 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http://creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.

The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory concentration [MIC] 3.2 μg/mL) but was inactive against other Candida species. When testing the susceptibility of cilofungin, 5-flucytosine and amphotericin B at the two centres, approximately 90% of the Candida strains had MICs differing by fourfold or less. However, when testing susceptibility of ketoconazole, only 51% of the Candida strains had MIC differences fourfold or less. MIC susceptibility testing with cilofungin, 5-flucytosine and amphotericin B in saam-f medium is reproducible.

 Antifungal susceptibility testing Candida species Cilofungin LY121019