Antiviral activity of arylnaphthalene and aryldihydronaphthalene lignans

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dc.contributor.authorCow, C
dc.contributor.authorLeung, C
dc.contributor.authorCharlton, JL
dc.date.accessioned2007-10-09T19:04:54Z
dc.date.available2007-10-09T19:04:54Z
dc.date.issued2003-03-31
dc.description.abstractA practical method for large scale synthesis of 1-arylnaphthalene and 1-aryl-1,2-dihydronaphthalene lignans is described. The method makes use of the classic Stobbe condensation followed by regioselective reactions that provide access to both the common and retrolactone lignans, e.g., 2 and 3. A total of 25 compounds, many of which are known natural products, were prepared and their antiviral activity against human cytomegalovirus measured.en
dc.format.extent130143 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citation0008-4042; CAN J CHEM, MAY 2000, vol. 78, no.5, p.553 to 561.en
dc.identifier.doihttp://dx.doi.org/10.1139/v00-059
dc.identifier.urihttp://hdl.handle.net/1993/2920
dc.language.isoengen_US
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dc.rightsopen accessen_US
dc.statusPeer revieweden
dc.subjectlignanen
dc.subjectStobbeen
dc.subjectarylnaphthaleneen
dc.subjectantiviralen
dc.subject1-ARYLNAPHTHALENE LIGNANen
dc.subjectNEOLIGNANSen
dc.subjectLACTONESen
dc.subjectINHIBITORen
dc.titleAntiviral activity of arylnaphthalene and aryldihydronaphthalene lignansen
dc.typejournal articleen_US
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