NF-&#954;B p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus

Oikawa, Kensuke; Odero, Gary L; Platt, Eric; Neuendorff, Melanie; Hatherell, Avril; Bernstein, Michael J; Albensi, Benedict C

NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus

dc.contributor.author	Oikawa, Kensuke
dc.contributor.author	Odero, Gary L
dc.contributor.author	Platt, Eric
dc.contributor.author	Neuendorff, Melanie
dc.contributor.author	Hatherell, Avril
dc.contributor.author	Bernstein, Michael J
dc.contributor.author	Albensi, Benedict C
dc.date.accessioned	2012-08-03T11:43:20Z
dc.date.available	2012-08-03T11:43:20Z
dc.date.issued	2012-05-03
dc.date.updated	2012-08-03T11:43:21Z
dc.description.abstract	AbstractBackgroundNuclear factor kappa B (NF-κB) is a transcription factor typically expressed with two specific subunits (p50, p65). Investigators have reported that NF-κB is activated during the induction of in vitro long term potentiation (LTP), a paradigm of synaptic plasticity and correlate of memory, suggesting that NF-κB may be necessary for some aspects of memory encoding. Furthermore, NF-κB has been implicated as a potential requirement in behavioral tests of memory. Unfortunately, very little work has been done to explore the effects of deleting specific NF-κB subunits on memory. Studies have shown that NF-κB p50 subunit deletion (p50−/−) leads to memory deficits, however some recent studies suggest the contrary where p50−/− mice show enhanced memory in the Morris water maze (MWM). To more critically explore the role of the NF-κB p50 subunit in synaptic plasticity and memory, we assessed long term spatial memory in vivo using the MWM, and synaptic plasticity in vitro utilizing high frequency stimuli capable of eliciting LTP in slices from the hippocampus of NF-κB p50−/− versus their controls (p50+/+).ResultsWe found that the lack of the NF-κB p50 subunit led to significant decreases in late LTP and in selective but significant alterations in MWM tests (i.e., some improvements during acquisition, but deficits during retention).ConclusionsThese results support the hypothesis that the NF-κ p50 subunit is required in long term spatial memory in the hippocampus.
dc.description.version	Peer Reviewed
dc.identifier.citation	BMC Neuroscience. 2012 May 03;13(1):45
dc.identifier.doi	http://dx.doi.org/10.1186/1471-2202-13-45
dc.identifier.uri	http://hdl.handle.net/1993/8143
dc.language.rfc3066	en
dc.rights	open access	en_US
dc.rights.holder	Kensuke Oikawa et al.; licensee BioMed Central Ltd.
dc.title	NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus
dc.type	Journal Article