White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia

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dc.contributor.authorXu, Haiyun
dc.contributor.authorLi, Xin-Min
dc.date.accessioned2015-05-14T16:56:11Z
dc.date.available2015-05-14T16:56:11Z
dc.date.issued2011-8-11
dc.date.updated2015-03-29T13:38:04Z
dc.description.abstractSchizophrenia is a severe mental disorder affecting about 1% of the population worldwide. Although the dopamine (DA) hypothesis is still keeping a dominant position in schizophrenia research, new advances have been emerging in recent years, which suggest the implication of white matter abnormalities in schizophrenia. In this paper, we will briefly review some of recent human studies showing white matter abnormalities in schizophrenic brains and altered oligodendrocyte-(OL-) and myelin-related genes in patients with schizophrenia and will consider abnormal behaviors reported in patients with white matter diseases. Following these, we will selectively introduce some animal models examining a putative role of white matter abnormalities in schizophrenia. The emphasis will be put on the cuprizone (CPZ) model. CPZ-fed mice show demyelination and OLs loss, display schizophrenia-related behaviors, and have higher DA levels in the prefrontal cortex. These features suggest that the CPZ model is a novel animal model of schizophrenia.
dc.description.versionPeer Reviewed
dc.identifier.citationHaiyun Xu and Xin-Min Li, “White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia,” Schizophrenia Research and Treatment, vol. 2011, Article ID 826976, 16 pages, 2011. doi:10.1155/2011/826976
dc.identifier.urihttp://dx.doi.org/10.1155/2011/826976
dc.identifier.urihttp://hdl.handle.net/1993/30521
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2011 Haiyun Xu and Xin-Min Li. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleWhite Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia
dc.typeJournal Article
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