MSpace - DSpace at UofM >
Faculty of Graduate Studies (Electronic Theses and Dissertations) >
FGS - Electronic Theses & Dissertations (Public) >

Please use this identifier to cite or link to this item:

Title: Dual-functional polyurea microcapsules for chronic wound care dressings: sustained drug delivery and non-leaching infection control
Authors: He, Wei
Supervisor: Liu, Song (Textile Sciences)
Examining Committee: Gu, Xiaochen (Faculty of Pharmacy) Zhong, Wen (Textile Sciences)
Graduation Date: October 2012
Keywords: microcapsule
wound dressing
chronic wound
Issue Date: 12-Jun-2012
Publisher: John Wiley and Sons
Citation: He, W., Gu, X. and Liu, S. (2012), Surfactant-Free One-Step Synthesis of Dual-Functional Polyurea Microcapsules: Contact Infection Control and Drug Delivery. Adv. Funct. Mater.. doi: 10.1002/adfm.201200656
Abstract: A new design of dual-functional polyurea microcapsules was proposed for chronic wound dressings to provide both non-leaching infection control and sustained topical drug delivery functionalities. Quaternary ammonium functionalized polyurea microcapsules (MCQs) were synthesized under mild conditions through an interfacial crosslinking reaction between branched polyethylenimine (PEI) and 2,4-toluene diisocyanate (TDI) in a dimethylformamide/cyclohexane emulsion. An in-situ modification method was developed to endow non-leaching surface antimicrobial properties to MCQs via bonding antimicrobial surfactants to surface isocyanate residues on the polyurea shells. The resultant robust MCQs with both non-leaching antimicrobial properties and sustained drug releasing properties have potential applications in medical textiles, such as chronic wound dressings, for infection control and drug delivery.
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

Files in This Item:

File Description SizeFormat
He_Wei.pdf2.37 MBAdobe PDFView/Open
View Statistics

Items in MSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! MSpace Software Copyright © 2002-2010  Duraspace - Feedback