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Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/8443

Title: Dual-functional polyurea microcapsules for chronic wound care dressings: sustained drug delivery and non-leaching infection control
Authors: He, Wei
Supervisor: Liu, Song (Textile Sciences)
Examining Committee: Gu, Xiaochen (Faculty of Pharmacy) Zhong, Wen (Textile Sciences)
Graduation Date: October 2012
Keywords: microcapsule
wound dressing
polyurea
chronic wound
Issue Date: 12-Jun-2012
Publisher: John Wiley and Sons
Citation: He, W., Gu, X. and Liu, S. (2012), Surfactant-Free One-Step Synthesis of Dual-Functional Polyurea Microcapsules: Contact Infection Control and Drug Delivery. Adv. Funct. Mater.. doi: 10.1002/adfm.201200656
Abstract: A new design of dual-functional polyurea microcapsules was proposed for chronic wound dressings to provide both non-leaching infection control and sustained topical drug delivery functionalities. Quaternary ammonium functionalized polyurea microcapsules (MCQs) were synthesized under mild conditions through an interfacial crosslinking reaction between branched polyethylenimine (PEI) and 2,4-toluene diisocyanate (TDI) in a dimethylformamide/cyclohexane emulsion. An in-situ modification method was developed to endow non-leaching surface antimicrobial properties to MCQs via bonding antimicrobial surfactants to surface isocyanate residues on the polyurea shells. The resultant robust MCQs with both non-leaching antimicrobial properties and sustained drug releasing properties have potential applications in medical textiles, such as chronic wound dressings, for infection control and drug delivery.
URI: http://hdl.handle.net/1993/8443
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

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