MSpace - DSpace at UofM >
Research Publications from University of Manitoba Researchers >
Research Publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/8143

Title: NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus
Authors: Oikawa, Kensuke
Odero, Gary L
Platt, Eric
Neuendorff, Melanie
Hatherell, Avril
Bernstein, Michael J
Albensi, Benedict C
Issue Date: 3-May-2012
Citation: BMC Neuroscience. 2012 May 03;13(1):45
Abstract: AbstractBackgroundNuclear factor kappa B (NF-κB) is a transcription factor typically expressed with two specific subunits (p50, p65). Investigators have reported that NF-κB is activated during the induction of in vitro long term potentiation (LTP), a paradigm of synaptic plasticity and correlate of memory, suggesting that NF-κB may be necessary for some aspects of memory encoding. Furthermore, NF-κB has been implicated as a potential requirement in behavioral tests of memory. Unfortunately, very little work has been done to explore the effects of deleting specific NF-κB subunits on memory. Studies have shown that NF-κB p50 subunit deletion (p50−/−) leads to memory deficits, however some recent studies suggest the contrary where p50−/− mice show enhanced memory in the Morris water maze (MWM). To more critically explore the role of the NF-κB p50 subunit in synaptic plasticity and memory, we assessed long term spatial memory in vivo using the MWM, and synaptic plasticity in vitro utilizing high frequency stimuli capable of eliciting LTP in slices from the hippocampus of NF-κB p50−/− versus their controls (p50+/+).ResultsWe found that the lack of the NF-κB p50 subunit led to significant decreases in late LTP and in selective but significant alterations in MWM tests (i.e., some improvements during acquisition, but deficits during retention).ConclusionsThese results support the hypothesis that the NF-κ p50 subunit is required in long term spatial memory in the hippocampus.
URI: http://hdl.handle.net/1993/8143
DOI: http://dx.doi.org/10.1186/1471-2202-13-45
Type: Journal Article
Appears in Collection(s):Research Publications

Files in This Item:

File Description SizeFormat
1471-2202-13-45.xml80.36 kBXMLView/Open
1471-2202-13-45.pdf1.27 MBAdobe PDFView/Open
View Statistics

Items in MSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! MSpace Software Copyright © 2002-2010  Duraspace - Feedback