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Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/5255

Title: Evaluation of the lipid-lowering efficacy of a water dispersible formulation of free sterols versus plant sterol esters in humans consuming a supplemented dairy product
Other Titles: Water dispersible plant sterol formulation shows improved lipid lowering efficacy compared to plant sterol esters
Authors: Amir Shaghaghi, Mandana
Supervisor: Jones, Peter (Human Nutritional Sciences, Food Sciences)
Examining Committee: Mymin, David (Medicine) Moghadasian, Mohammad (Human Nutritional Sciences) Harding, Scott (Diabetes and Nutritional Sciences Division, King's College, London, United Kingdom)
Graduation Date: May 2012
Keywords: Esterified plant sterols
Cholesterol absorption
Water dispersible plant sterol
Issue Date: 4-Apr-2012
Abstract: Reduced bioavailability in some formulations of phytosterols accounts for the variable results observed in LDL- C- lowering efficacy among trials. This study examined the effects of a water-dispersible formulation of free phytosterols (WD-PS) versus phytosterol esters (PS-esters) on plasma lipid and fat soluble vitamins concentrations in hypercholesterolemic individuals. Using a double-blind, randomized, crossover study, 47 hypercholesterolemics were provided for 4 wk: WD-PS-enriched yogurt (2g/d), PS-esters-enriched yogurt (2g/d), or yogurt alone (placebo), in a random order. Each study phase was separated by 4 wk washout intervals. Supplementation of WD-PS or PS-esters similarly decreased serum TC (7.7% and 6.3%, respectively) and LDL-C levels (11.7% and 11.6%, respectively, p<0.001). The ratio of TC/ HDL-C decreased for WD-PS (10.6%, p<0.05) but not for PS-esters. Moreover, WD-PS reduced serum TG (13.9%, p<0.05) as compared to PS-esters (0.6%). The results of the current study confirm the importance of the formulation of phytosterols in their bioavailability and efficacy.
URI: http://hdl.handle.net/1993/5255
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

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