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Title: Nanosecond pulse electroporation of biological cells: The effect of membrane dielectric relaxation
Authors: Salimi, Elham
Supervisor: Bridges, Greg (Electrical and Computer Engineering)
Examining Committee: Thomson, Douglas (Electrical and Computer Engineering) Lin, Francis (Physics and Astronomy)
Graduation Date: May 2011
Keywords: Electroporation
Dielectric dispersion
Debye relaxation model
Issue Date: 7-Apr-2011
Abstract: Nanosecond pulse electroporation of biological cells is gaining significant interest due to its ability to influence intracellular structures. In nanosecond pulse electroporation of biological cells nanosecond duration pulses with high frequency spectral content are applied to the cell. In this research we show that accurate modeling of the nanosecond pulse electroporation process requires considering the effect of the membrane dielectric relaxation on the electric potential across the membrane. We describe the dielectric relaxation of the membrane as dispersion in the time-domain and incorporate it into the nonlinear asymptotic model of electroporation. Our nonlinear dispersive model of a biological cell is solved using finite element method in 3-D space enabling arbitrary cell structures and internal organelles to be modeled. The simulation results demonstrate two essential differences between dispersive and non-dispersive membrane models: the process of electroporation occurs faster when the membrane dispersion is considered, and the minimum required electric field to electroporate the cell is significantly reduced for the dispersive model.
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

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