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Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/4140

Title: MULTIPLE SCLEROSIS INDUCED NEUROPATHIC PAIN
Authors: BEGUM, FARHANA
Supervisor: Namaka, Michael(Faculty of Pharmacy)
Examining Committee: Frost, Emma (Faculty of Pharmacy), Klonisch, Thomas (Human Anatomy and Cell Science)
Graduation Date: October 2010
Keywords: MULTIPLE SCLEROSIS
NEUROPATHIC PAIN
TUMOR NECROSIS FACTOR ALPHA
Issue Date: 10-Sep-2010
Abstract: Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Antigen induced activation of Th1 cells in the peripheral blood leads to elevated production of inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) that have been directly linked to disease induction and neuropathic pain. It was hypothesized that following antigenic induction, cytokines gain access to the spinal cord and participate in direct cellular interaction with dorsal horn neurons. Using an animal model of MS, we show that TNF-α gene and protein expression in the dorsal root ganglia (DRG) and spinal cord tissue is increased in the active group. In addition, our findings show TNF-α mRNA expression in the dorsal root entry point. Therefore, our results support the hypothesis that antigen induced DRG derived TNF-α can transport to the spinal cord via the dorsal roots and is involved in the underlying pathogenesis of MS induced neuropathic pain.
URI: http://hdl.handle.net/1993/4140
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

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