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Title: The potential of proton magnetic resonance spectroscopy (1H MRS) in detecting early colonic inflammation and assessing the effect of various dietary fatty acids on modulation of inflammatory bowel disease in an animal model
Authors: Varma, Sonal
Supervisor: Bezabeh, Tedros (Human Nutritional Sciences) Eskin, Michael (Human Nutritional Sciences)
Examining Committee: Begleiter, Asher (Pharmacology) Taylor, Carla (Human Nutritional Sciences)
Graduation Date: May 2008
Keywords: Beef tallow
Colon cancer
Corn oil
Flaxseed oil
Inflammatory bowel disease
Proton magnetic resonance spectroscopy
Statistical classification strategy
ω-3 polyunsaturated fatty acids
Issue Date: 14-May-2008
Citation: Varma, S, Bird, R, Eskin, M, Dolenko, B, Raju, J, Bezabeh, T. (2007). Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal model. J Inflamm 26 (4): 24-30.
Abstract: The objectives of our study were to determine the potential of 1H MRS in detecting (1) early colonic inflammation, (2) effects of various fatty acids on normal colon and (3) their effects on IBD. Sprague dawley rat fed with 2% carrageenan was used as a model of IBD. Flaxseed oil served as ω-3, corn oil as ω-6 and beef tallow as saturated fatty acid sources. Control group animals were fed 5% corn oil, whereas, those in high-fat diet groups received an additional 7% of the respective fatty acids. After 2 weeks, 1H MRS and histology were conducted on excised colonic mucosa. Statistical classification strategy (SCS) used for analyzing 1H MRS data achieved an accuracy of 82 % in stage 1, 90-100% in stage 2 and 96-100% in stage 3. This implies that 1H MRS is a sensitive tool to diagnose early IBD and the effects of dietary fat on IBD.
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

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