MSpace - DSpace at UofM >
Research Publications from University of Manitoba Researchers >
Research Publications (UofM Student, Faculty and Staff only access) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/3013

Title: Pattern of insulin delivery affects hepatic insulin sensitizing substance (HISS) action and insulin resistance
Authors: Reid, MAG
Lautt, WW
Keywords: pulsatile
glucose uptake
RIST
euglycemic clamp
insulin sensitivity
SENSITIVITY TEST RIST
PULSATILE INSULIN
CHOLINERGIC BLOCKADE
GLUCOSE DISPOSAL
EUGLYCEMIC CLAMP
PULSE FREQUENCY
PLASMA-GLUCOSE
OSCILLATIONS
HYPERINSULINEMIA
SECRETION
Issue Date: 31-Dec-2004
Citation: 0008-4212; CAN J PHYSIOL PHARMACOL, DEC 2004, vol. 82, no. 12, p.1068 to 1074.
Abstract: Hepatic insulin sensitizing substance (HISS) action accounts for 55% of the glucose disposal effect of a bolus of insulin in the fed state. To determine the effect of continuous versus pulsatile insulin delivery on HISS action in male Sprague-Dawley rats, insulin sensitivity was assessed using the rapid insulin sensitivity test (RIST) before and after a continuous, pulsatile, or bolus insulin (60 mU/kg i.v.) delivery. There was a significant difference in the RIST index after a continuous insulin infusion (247.9 mg/kg before, 73.2 mg/kg after) but not after 3 pulses where insulin action returned to baseline between pulses (211.6 mg/kg before, 191.0 mg/kg after) or single bolus (205.8 mg/kg before, 189.9 mg/kg after) insulin infusion. If a 3-pulse infusion was timed so that insulin action did not return to baseline between pulses, HISS action was suppressed. Continuous insulin infusion (10-30 min) showed progressive postinfusion blockade of HISS action. To maintain HISS-dependent insulin action, continuous insulin infusions should be avoided.
URI: http://hdl.handle.net/1993/3013
DOI: http://dx.doi.org/10.1139/y04-111
Appears in Collection(s):Research Publications (UofM Student, Faculty and Staff only access)

Files in This Item:

File Description SizeFormat
Reid_Pattern_of_insulin.pdf297 kBAdobe PDFView/Open
View Statistics

Items in MSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! MSpace Software Copyright © 2002-2010  Duraspace - Feedback