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Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/3009

Title: Increased incidence of hepatic insulin-sensitizing substance (HISS)-dependent insulin resistance in female rats prenatally exposed to ethanol
Authors: Sadri, P
Legare, DJ
Takayama, S
Lautt, WW
Keywords: fetal
alcohol
insulin resistance
gender
HISS
teratology
diabetes
SELECTIVE FETAL MALNUTRITION
HUMAN UMBILICAL ARTERY
PERINATAL ALCOHOL
SENSITIVITY
INVITRO
INTERRUPTION
BLOCKADE
STRESS
Issue Date: 30-Apr-2005
Citation: 0008-4212; CAN J PHYSIOL PHARMACOL, APR 2005, vol. 83, no. 4, p.383 to 387.
Abstract: Insulin causes the release of the hepatic insulin-sensitizing substance (HISS) from the liver. Hepatic parasympathetic nerves play a permissive role in the release of HISS. HISS-dependent insulin resistance (HDIR) occurs in the absence of HISS. Fetal ethanol exposure has been shown to cause dose-dependent HDIR in adult male rat offspring. Since female offspring are more severely affected by in utero ethanol toxicity, we hypothesized that fetal alcohol exposure causes higher incidence and more severe HDIR in adult female offspring. Adult female rat offspring prenatally exposed to different concentrations of ethanol (0%, 15%, and 20%) were tested for insulin sensitivity using the rapid insulin sensitivity test (RIST). The RIST index was significantly reduced in the 15% (134.1 +/- 16.1 mg/kg) and the 20% (98.7 +/- 9.7 mg/kg) group compared with the 0% (220.9 +/- 27.6 mg/kg) group. Administration of atropine produced significant additional HDIR in the 15% group (82.9 +/- 14.5 mg/kg) but not the 20% group (83.8 +/- 20.5 mg/kg) indicating complete HDIR had been produced in this group, contrary to the adult male offspring in a previous study. The results are consistent with the hypothesis that adult-female offspring are more severely affected by in utero ethanol exposure compared with adult-male offspring.
URI: http://hdl.handle.net/1993/3009
DOI: http://dx.doi.org/10.1139/y05-023
Appears in Collection(s):Research Publications (UofM Student, Faculty and Staff only access)

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