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Title: Dietary zinc deficiency and expression of T lymphocyte signal transduction proteins
Authors: Taylor, CG ; Giesbrecht J-AC
Keywords: zinc
T lymphocytes
signal transduction
immune function
Issue Date: 31-Dec-2004
Citation: 0315-1468; CAN J CIVIL ENG, DEC 2004, vol. 31, no. 6, p.943 to 955.
Abstract: Impaired immune function in dietary zinc (Zn) deficiency is characterized in part by reduced lymphocyte numbers (lymphopenia) and depressed cell-mediated (T lymphocyte) immune function, however, the causative mechanisms at the molecular level have not been elucidated. This paper will focus on the role of dietary Zn in T lymphocyte signal transduction, and specifically, the early Zn-dependent steps for phosphorylation and the putative Zn-finger proteins or Zn-metalloenzymes that may be part of the molecular mechanism for explaining immune dysfunction in Zn deficiency. One of the major recent findings is that murine splenic T lymphocyte p56(lck) expression is elevated in dietary Zn deficiency and caloric deficiency. Based on the known functions of p56(lck), it is proposed that elevated p56(lck) may contribute to altered thymocyte maturation, apoptosis, and lymphopenia in dietary Zn deficiency and other malnutrition syndromes.
Appears in Collection(s):Research Publications (UofM Student, Faculty and Staff only access)

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