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Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/2920

Title: Antiviral activity of arylnaphthalene and aryldihydronaphthalene lignans
Authors: Cow, C
Leung, C
Charlton, JL
Keywords: lignan
Stobbe
arylnaphthalene
antiviral
1-ARYLNAPHTHALENE LIGNAN
NEOLIGNANS
LACTONES
INHIBITOR
Issue Date: 31-Mar-2003
Citation: 0008-4042; CAN J CHEM, MAY 2000, vol. 78, no.5, p.553 to 561.
Abstract: A practical method for large scale synthesis of 1-arylnaphthalene and 1-aryl-1,2-dihydronaphthalene lignans is described. The method makes use of the classic Stobbe condensation followed by regioselective reactions that provide access to both the common and retrolactone lignans, e.g., 2 and 3. A total of 25 compounds, many of which are known natural products, were prepared and their antiviral activity against human cytomegalovirus measured.
URI: http://hdl.handle.net/1993/2920
DOI: http://dx.doi.org/10.1139/v00-059
Appears in Collection(s):Research Publications (UofM Student, Faculty and Staff only access)

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