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http://hdl.handle.net/1993/2920
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| Title: | Antiviral activity of arylnaphthalene and aryldihydronaphthalene lignans |
| Authors: | Cow, C
Leung, C
Charlton, JL |
| Keywords: | lignan
Stobbe
arylnaphthalene
antiviral
1-ARYLNAPHTHALENE LIGNAN
NEOLIGNANS
LACTONES
INHIBITOR
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| Issue Date: | 31-Mar-2003 |
| Citation: | 0008-4212; CAN J PHYSIOL PHARMACOL, MAR 2003, vol. 81, no. 3, p.220 to 233. |
| Abstract: | A practical method for large scale synthesis of 1-arylnaphthalene and 1-aryl-1,2-dihydronaphthalene lignans is described. The method makes use of the classic Stobbe condensation followed by regioselective reactions that provide access to both the common and retrolactone lignans, e.g., 2 and 3. A total of 25 compounds, many of which are known natural products, were prepared and their antiviral activity against human cytomegalovirus measured. |
| URI: | http://hdl.handle.net/1993/2920 |
| Appears in Collections: | Research Publications
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