MSpace - DSpace at UofM >
Research Publications from University of Manitoba Researchers >
Research Publications (UofM Student, Faculty and Staff only access) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1993/2897

Title: Sarpogrelate diminishes changes in energy stores and ultrastructure of the ischemic-reperfused rat heart
Authors: Temsah, RM
Kumamoto, H
Takeda, N
Dhalla, NS
Keywords: ischemia reperfusion
sarpogrelate
serotonin receptor blockade
CARDIAC MAST-CELLS
RECEPTOR ANTAGONIST
SEROTONIN
5-HYDROXYTRYPTAMINE
KETANSERIN
DISEASE
5-HT
MECHANISMS
MCI-9042
Issue Date: 30-Sep-2001
Citation: 0008-4212; CAN J PHYSIOL PHARMACOL, SEP 2001, vol. 79, no. 9, p.761 to 767.
Abstract: Although the involvement of serotonin in exacerbating vascular abnormalities in ischemic heart disease has been established, its role in mediating changes in cardiac function due to ischemia reperfusion (IR) is poorly understood. The aim of this study was to investigate the effect of a serotonin blocker, sarpogrelate (5-HT2A antagonist), in preventing cardiac injury due to IR. Isolated rat hearts were subjected to 30 min of global ischemia followed by 1 h of reperfusion. Sarpogrelate (50 nM-0.9 muM) was infused 10 min before ischemia as well as during the reperfusion period. The IR-induced changes in left ventricular developed pressure, left ventricular end diastolic pressure, rate of pressure development, and rate of pressure decay were attenuated (P < 0.05) with sarpogrelate treatment. Sarpogrelate also decreased the ultrastructural damage and improved the high energy phosphate level in the IR hearts (P < 0.05). This study provides evidence for the attenuation of IR-induced cardiac injury by 5-HT2A receptor blockade and supports the view that serotonin may contribute to the deleterious effects of IR in the heart.
URI: http://hdl.handle.net/1993/2897
DOI: http://dx.doi.org/10.1139/y01-047
Appears in Collection(s):Research Publications (UofM Student, Faculty and Staff only access)

Files in This Item:

File Description SizeFormat
Temsah_Sarpogrelate_diminishes.pdf368.36 kBAdobe PDFView/Open
View Statistics

Items in MSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! MSpace Software Copyright © 2002-2010  Duraspace - Feedback