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Title: Effects of post-pulmonary resection on maximal deflation in normal and emphysematous lungs in dogs
Authors: Ewing-Bui, Tinh David
Issue Date: 1-Jul-2000
Abstract: This investigation examines the role of interdependence of maximal expiratory flow between lobes in normal canine lungs and a heterogeneous emphysema model. Dogs weighing from 17 to 30 kg were used. In one group of animals (n = 11), the lungs were normal. In the other group (n = 5), RLL emphysema was produced by the enzyme papain. Three instillations of papain were administered two weeks apart under bronchoscopic visualization into the RLL while the animal was anesthetized and ventilated. In the latter group, measurements were approximately three weeks after the last dose of papain was administered. The results showed that within the groups of normal dogs, the RLL deflated significantly slower and had lower expiratory flows than when it was deflated in the presence of adjacent lobes. Similar results occurred within the group of emphysematous dogs. Within each group of dogs, the bronchial cross-sectional area in condition
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