MSpace - DSpace at UofM >
Faculty of Graduate Studies (Electronic Theses and Dissertations) >
FGS - Electronic Theses & Dissertations (Public) >

Please use this identifier to cite or link to this item:

Title: Liver maldevelopment in the fetal alcohol syndrome
Authors: Meyers, Adrienne F. A.
Issue Date: 1-Aug-1998
Abstract: Previous studies have documented that liver/body weight ratios and rates of hepatic DNA synthesis are decreased in a rat model of fetal alcohol syndrome (FAS). In an attempt to determine the mechanism(s) responsible for these findings, rates of liver maturation, liver histology, and the status of the growth hormone (GH)/insulin-like growth factor (IGF)/insulin-like growth factor binding protein (IGFBP) axis were documented in FAS pups during gestation and the post-partum period and compared with control animals. Pregnant Sprague-Dawley rats were fed a liquid diet containing ethanol as 36% of the total calories, an isocaloric control liquid diet, or had ad lib access to the control liquid diet throughout pregnancy. Dams were continued on their respective diets until weaning. Upon weaning, pups were fed control liquid diet until the time of sacrifice. Sacrifices were performed at gestational days 16 and 20 and post-partum days 1, 7, and 40. Albumin, alpha fetoprotein, growth hormone receptor, IGF-1, IGF-II, and IGFBP-1, -2, -3, -4 mRNA were documented at each time point by Northern Blot Analyses. In 40 day old pups, serum glucose, insulin, glucagon and insulin sensitivity were also determined by commercial assays and a rapid insulin sensitivity test (RIST) respectively. (Abstract shortened by UMI.)
Appears in Collection(s):FGS - Electronic Theses & Dissertations (Public)

Files in This Item:

File Description SizeFormat
MQ32190.pdf3.62 MBAdobe PDFView/Open
View Statistics

Items in MSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! MSpace Software Copyright © 2002-2010  Duraspace - Feedback